The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235
Mechanistic Focus in Research Within experimental laboratory environments, FOXO4-DRI is often studied in relation to cellular signalling pathways associated with senescence and protein interaction dynamics
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Stenovec, M., Li, B., Verkhratsky, A
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